| Ippo Makunouchi is a very shy high school student who never had the time to make friends because he was always busy helping his mother with the family charter boat fishing business. Because he kept to himself, a group of bullies led by Umezawa got into the habit of picking on him. On one particular day these bullies decided to give him a rather serious beating, but a middle-weight professional boxer who was passing by stopped the bullies and took the injured Ippo to the Kamogawa Gym, owned by retired boxer Genji Kamogawa, to treat his wounds. After Ippo awoke to the sounds of boxers training, the boxer who saved him, Mamoru Takamura, tried to cheer Ippo up by letting him vent his frustrations on a sandbag. It was then that they had their first glimpse into Ippo's talent for boxing. After that incident, Ippo started his regular training and began his path in Japan's professional boxing. The story focuses heavily on character development, even during the matches something is learned about the fighters. Ippo and his friendly rivalry with Miyata is the main draw in the early part of the series. That later changes to Ippo's path towards the Japanese Featherweight Championship and eventually the world championship. Along the way we are given glimpses into the other side character's pasts, motivations, relationships to others and current boxing trials. The anime series has two spin-off movies that were actually part of the manga. Champion Road, which takes place after Ippo becomes the Japanese Featherweight Champion and showcases his first defense of the title, and Kimura Vs. Mashiba, which pits one of Ippo's upper classmen (Kimura) against the Japanese Junior Lightweight Champion Mashiba (the brother of Ippo's love interest).
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| Makunouchi Ippo: The kind and easily intimidated titular hero of the series, Ippo wishes to become stronger, both physically and mentally. As fate would have it, he meets Mamoru Takamura who introduces him to the world of boxing. From that moment on Ippo tirelessly trains to become a pro boxer and overcome his fears. As a boxer, Ippo's greatest strength lies in his undying willpower and his natural physical strengths, which include monstrous stamina through training, and raw physical power. Whenever he can, he helps his mother (Hiroko) at home with the family charter boat fishing business.
| STATS:- Eastern Japan Rookie King (Awarded MVP)
- All Japan Rookie King (Awarded MVP)
- Japan Featherweight Champion
- 22 matches 21-1-0 (W-L-D) 21 KOs
- RANK: C (JBC), 8/9 (WBC), 1 (OPBF)
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| Mamoru Takamura: A veteran boxer who introduces Ippo to the sport after rescuing him from bullies. Gifted with incredible physical ability, he is one of the few Japanese boxers that made it to the world stage. As a result of his incredible skill, Takamura has an equally large ego and is not above bad-mouthing his enemies, teammates, and even Coach Kamogawa. He is the estranged son of a family that runs a large line of successful hotels and resorts, and was quite a troublemaker until Coach Kamogawa managed to get him out of a life of street violence. Currently, Takamura is the reigning WBC Middleweight Champion, and former WBC Light Middleweight Champion. He takes pride in helping his friends and fellow boxers, especially Ippo, whom he has personally taken under his wing. His current aspiration is to conquer the next four classes up through heavyweight.
| STATS:- Eastern Japan Rookie King
- All Japan Rookie King
- Japan Middleweight Champion
- WBC Junior Middleweight Champion
- WBC Middleweight Champion
- 22 matches 22-0-0 (W-L-D) 22 KOs
- RANK: C (WBC)
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| Miyata Ichiro: Ippo's greatest rival. Not only is the taciturn Miyata a boxing prodigy, but he is also blessed with good looks, amazing reflexes, and nearly unmatched speed. He began at the Kamogawa Gym, but later transferred to Kawahara Gym in hopes of one day facing Ippo in an official match. Miyata trained all across the Pacific and eventually returned to the mainstream boxing scene as the OPBF (Orient Pacific Boxing Federation) featherweight champion. Miyata himself looked down on Ippo a little at first, but after he helped Ippo to buy new boots for their first match, he started to respect him more, developing a friendly rivalry.
| STATS:- OPBF Featherweight Champion
- 25 matches 23-1-1 (W-L-D) 21 KOs
- RANK: 7 (WBC), C (OPBF)
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| Genji Kamogawa: Head coach and founder of the Kamogawa gym. He fought as a prizefighter in Japan shortly after the end of World War II. Along with his friends, Ginpachi Nekota and Dankichi Hama, Kamogawa developed a style of fighting that both presumably became the forerunner of boxing in Japan and emphasized scientific theory in its techniques. As a coach, Kamogawa's wealth of knowledge and experience has been tapped into on multiple occasions during training as well as in matches. Although he rarely admits it aloud, he is extremely proud of his two best boxers, Takamura and Ippo.
| STATS:- Kamogawa Gym Coach/Owner
- 8 matches 5-2-1 (W-L-D) 5 KOs
- RANK: Retired
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| Tatsuya Kimura: Ippo's senpai and Aoki's best friend. He is the smooth, collected type and a romantic at heart, but trains as hard as anyone. His style incorporates a fast left and faster footwork. In the past, he and Aoki were the toughest high-school thugs around, but now Tatsuya's real job is at his family's flower shop. After losing to Ryo Mashiba, he announced his retirement from boxing. Shortly after, unable to stay away from boxing, he returned saying he would spell his name in katakana instead of kanji.
| STATS:- Out Boxer
- Fought Mashiba for Jr. Lightweight Championship
- 21 matches 14-4-3 (W-L-D) 9 KOs
- RANK: 7 (JBC)
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| Masaru Aoki: Ippo's senpai and Kimura's best friend. Aoki provides much of the gym's comic relief and exercises one of the world's most unusual fighting styles. In the past, he and Kimura were the toughest high-school thugs around, but now Aoki's real job is at a ramen restaurant. He shares an apartment with his girlfriend, Tomiko, a friend of Kumi Mashiba whose nice personality and good body more than compensate for her less-than-stellar face.
| STATS:- Infighter
- Fought Imae Katsutaka fot Lightweight Championship
- 20 matches 11-6-3 (W-L-D) 7 KOs
- RANK: 7 (JBC)
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