| Born in the village of Resembool from the country of Amestris, the two brothers lived there with their parents. Their father, Hohenheim, left home for unknown reasons and years later, their mother, Trisha Elric, died of a terminal illness leaving the Elric brothers alone. After their mother's death, Edward becomes determined to bring her back through the use of alchemy, an advanced science in which objects can be created from raw materials. They researched Human Transmutation, a forbidden art in which one attempts to create or modify a human being. However, this attempt failed, ultimately resulting in the loss of Edward's left leg and right arm and Alphonse's entire body. In a desperate effort to save his brother, Edward sacrificed his right arm to affix his brother's soul to a suit of armour. Some days later, an alchemist named Roy Mustang visits the Elric brothers, and he tells Edward to become a member of the State Military of the country to find a way to recover their bodies. After that, Edward's left leg and right arm are fitted with two sets of automail, a type of advanced prosthetic limb, created for him by his close family friends Winry Rockbell and her grandmother Pinako. Edward sets out to become a State Alchemist, an alchemist employed by the State Military of Amestris, which infamously annihilated much of the neighbouring country of Ishbal's population in the past decade. Becoming a State Alchemist enables Edward to use the extensive resources available to State Alchemists, but it also turns him into what they call a "dog of the military". His more friendly relationship with Roy Mustang however, whom he reports to and who recruited him, allows the brothers freedom to search for the Philosopher's Stone as part of Edward's research, as each State Alchemist is expected to independently research new things which may be of a use to the State Military of Amestris. The brothers set off in search of the Philosopher's Stone as a means to restore their bodies. Throughout their journey, they meet many antagonists, including those who are willing to do anything to obtain the Philosopher's Stone; Scar, one of the few surviving Ishbalans, who seeks vengeance on the State Alchemists for the destruction of his race; and the homunculi, a group of human-like creatures who carry pieces of the Philosopher's Stone inside themselves, and from it derive the ability to survive almost any harm.
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| Edward Elric: The main protagonist, Edward ("Ed") Elric is the famous Fullmetal Alchemist, though Al is occasionally mistaken for him because of his armoured body. He has a prosthetic automail arm and leg, is of short stature, and typically reacts in an exaggerated manner to any remarks about his height. He is known for being the youngest State Alchemist, gaining this title at the age of 12.
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| Alphonse Elric, often nicknamed "Al," is Fullmetal Alchemist's secondary protagonist; he is Edward's younger brother and the narrator of the series. For most of the series his soul is trapped in a large suit of armour, causing other characters throughout the series to confuse Al with the "Fullmetal" Alchemist. Alphonse is the calmer of the two, and can be seen as a foil to Edward's character.
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| Colonel Roy Mustang is known as the Flame Alchemist. His gloves are made of a special material called "ignition cloth," which allows him to create a spark by snapping his fingers. He then uses alchemy to change the oxygen density in the air with the help of transmutation circles on his gloves, causing a controlled explosion. He is Edward's direct superior officer in the military, but has his own goal, mainly to become the Fuhrer, leader of the military.
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| Winry Rockbell is a mechanical expert who is a childhood friend of the Elrics. She, along with her grandmother Pinako, built Edward's automail, and she also helps maintain the automail when it gets broken. Her parents were called into service as doctors for the Ishbalan Civil War and were killed.
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